COLUMBIA, Mo. (AP) - Blaine Gabbert threw two touchdown passes before leaving with a hip pointer after three quarters and No. 24 Missouri got several big plays on special teams along with stout defense in a 26-0 victory over Colorado in a Big 12 opener on Saturday night.

The Tigers (5-0, 1-0 Big 12) had four sacks and an interception in their fifth straight victory over Colorado (3-2, 0-1) by a total score of 203-40. This one came just a few days after the 20th anniversary of the infamous Fifth Down game in 1990, which helped the Buffaloes win their only national championship.

Missouri struggled most of the game offensively other than a 97-yard, 15-play drive capped by Gabbert's 10-yard touchdown pass to Michael Egnew near the end of the half. Those woes were masked by a blocked field goal, blocked punt, fake punt and safety in the school's first shutout since blanking the Buffaloes 58-0 Oct. 25, 2008 at home.

Punter Trey Barrow's 26-yard run on a fake was enough to lead Missouri until backup quarterback James Franklin passed him in the fourth quarter, finishing with 37 yards on four carries and throwing a 10-yard touchdown pass to Michael Egnew.

Rodney Stewart had 91 yards on 18 carries for Colorado, but quarterback Tyler Hansen was yanked near the end of the third quarter. The Buffaloes advanced to the Missouri 18 before running out of downs near the end of the game.

Penalties helped to doom two fourth down chances in Missouri territory for Colorado, which has been outscored 78-7 in two road games this season.

Colorado trailed 19-0 at the half, and was outscored 86-3 the first half the last three years in the series.

Barrow and Matt Grabner had punts downed at the 2 and 1 in the first half. Eric Waters partially deflected a punt in the first half and pressure by Luke Lambert on the pass rush forced Hansen's intentional grounding call for the safety.