STILLWATER, Okla. (AP) -Brandon Weeden passed for 409 yards and six touchdowns, three to Justin Blackmon, and Oklahoma State set a school record for total offense in a 65-28 victory against Tulsa on Saturday night.

Weeden's effort ranked fourth on Oklahoma State's single-game passing chart, even though he left the game after one series in the third quarter, following an 81-yard scoring pass to Blackmon, the sixth-longest pass play in school history. He completed 23 of 32 passes.

The teams combined for 1,150 yards of offense, including 722 by Oklahoma State, breaking the school record of 717 set against Kansas during Barry Sanders' Heisman Trophy season in 1988.

Blackmon had six catches for 174 yards and has nine touchdowns this season.

Oklahoma State is 3-0 for the 19th time and the fourth time in six seasons under coach Mike Gundy.

G.J. Kinne passed for 219 yards but threw three interceptions for Tulsa (1-2), which hasn't beaten the Cowboys since 1998 and hasn't won at Oklahoma State since 1951. The Cowboys posted their highest point total in 71 games against Tulsa.

Since 2003, the Golden Hurricane are 0-10 against teams from BCS conferences. Tulsa's records only go back to 1940, but since then, the Golden Hurricane had never surrendered more than six touchdown passes in a game before the Cowboys had eight on Saturday.

It was the first time the two schools - separated by about 73 miles - had played since 2004. Tulsa entered the game ranked fourth in the nation in total offense while Oklahoma State was eighth, but the offensive showdown materialized on only one side.

Oklahoma State posted its second 65-point outing of the season. It scored that many points in the season opener against Washington State.

Weeden had one of the best passing halves ever by an Oklahoma State quarterback, completing 22 of 31 passes for 328 yards and five touchdowns as the Cowboys raced to a 41-7 halftime lead. Weeden's first-half yardage total would have ranked 11th on the school's single-game passing chart.

The first of Dan Bailey's three field goals, from 49 yards, gave the Cowboys a 3-0 lead, then Weeden's passing onslaught began. He threw a 1-yard touchdown to Michael Harrison - Harrison's first career catch. Two series later, Hubert Anyiam just squeezed into the end zone to complete an 18-yard scoring pass.

Tulsa pulled within 20-7 on a 1-yard sneak by Kinne, but Weeden answered with a 7-yard scoring pass to Blackmon. Tulsa appeared poised to score again, but Andrew McGee intercepted a Kinne pass in the end zone and returned it 79 yards. On the next play, Weeden hit Blackmon for a 21-yard score.

Weeden capped the half with a 19-yard TD pass to Josh Cooper 14 seconds before intermission.

On his only pass of the second half, Weeden hit Blackmon in stride at the Tulsa 40, and the receiver stepped out of a tackle and sprinted to the end zone.

Even in Weeden's absence, the Cowboys' aerial fireworks continued. Backup Clint Chelf threw a 10-yard scoring pass to Anyiam to make it 58-7 and hit Charlie Moore for a 27-yard score in the fourth quarter.

With 574 passing yards, Oklahoma State broke the school single-game record of 430, set against Texas in 2007. The eight touchdown passes broke the team record of seven, set in 2003 against Southern Methodist.

Oklahoma State didn't punt until 2:18 remained in the third quarter.

In the fourth quarter, Tulsa's Marco Nelson returned an interception 81 yards for a touchdown, the fourth-longest such return in school history and the longest since 1963.